Epidemiological Trends of Pediatric Inflammatory Bowel Disease in Korea: A Multicenter Study of the Last 3 Years Including the COVID-19 Era
Journal of Korean Medical Science 2022³â 37±Ç 37È£ p.279 ~ p.279
ÃÖ¼ÒÀ±(Choi So-Yoon) - Kosin University College of Medicine Kosin University Gospel Hospital Department of Pediatrics
ÃÖ¼öÁø(Choi Su-Jin) - Kyungpook National University School of Medicine Kyungpook National University Children¡¯s Hospital Department of Pediatrics
°ºó(Kang Ben) - Kyungpook National University School of Medicine Kyungpook National University Children¡¯s Hospital Department of Pediatrics
ÃÖº´È£(Choe Byung-Ho) - Kyungpook National University School of Medicine Kyungpook National University Children¡¯s Hospital Department of Pediatrics
ÀÌ¿¬ÁÖ(Lee Yeoun-Joo) - Pusan National University Children¡¯s Hospital Department of Pediatrics
¹ÚÀçÈ«(Park Jae-Hong) - Pusan National University Children¡¯s Hospital Department of Pediatrics
±èÀ¯ºó(Kim Yu-Bin) - Ajou University School of Medicine Department of Pediatrics
±èÀ翵(Kim Jae-Young) - Gyeongsang National University Changwon Hospital Department of Pediatrics
À̰ǼÛ(Lee Kun-Song) - Dankook University Hospital Department of Pediatrics
ÀÌ°æÀç(Lee Kyung-Jae) - Hallym University Sacred Heart Hospital Department of Pediatrics
°±â¼ö(Kang Ki-Soo) - Jeju National University Hospital Department of Pediatrics
ÀÌÀ¯¹Î(Lee Yoo-Min) - Soonchunhyang University College of Medicine Soonchunhyang University Bucheon Hospital Department of Pediatrics
±èÇöÁø(Kim Hyun-Jin) - Chungnam National University College of Medicine Chungnam National University Hospital Department of Pediatrics
°À±±¸(Kang Yun-Koo) - Yonsei University Wonju College of Medicine Department of Pediatrics
ÀåÈ¿Á¤(Jang Hyo-Jeong) - Keimyung University School of Medicine Keimyung University Dongsan Medical Center Department of Pediatrics
ÀÌ´ë¿ë(Yi Dae-Yong) - Chung-Ang University College of Medicine Chung-Ang University Hospital Department of Pediatrics
È«¼®Áø(Hong Suk-Jin) - Daegu Catholic University School of Medicine Department of Pediatrics
ÃÖÀ¯Áø(Choi You-Jin) - Inje University College of Medicine Inje University Ilsan Paik Hospital Department of Pediatrics
È«Áö³ª(Hong Jea-Na) - Kangwon National University School of Medicine Department of Pediatrics
±è¼øö(Kim Soon-Chul) - Jeonbuk National University Medical School and Hospital Department of Pediatrics
Abstract
Background: Studies on how the coronavirus pandemic has affected pediatric inflammatory bowel disease (PIBD) are lacking. We aimed to investigate the trends in epidemiology, characteristics, initial management, and short-term outcomes of PIBD in South Korea over the recent three years including the era of coronavirus disease 2019 (COVID-19).
Methods: This multicenter study retrospectively investigated temporal trends in the epidemiology of PIBD in Korea. Annual occurrences, disease phenotypes, and initial management at diagnosis were analyzed from January 2018 to June 2021.
Results: A total of 486 patients from 17 institutions were included in this epidemiological evaluation. Analysis of the occurrence trend confirmed a significant increase in PIBD, regardless of the COVID-19 pandemic. In Crohn¡¯s disease, patients with post-coronavirus outbreaks had significantly higher fecal calprotectin levels than those with previous onset (1,339.4 ¡¾ 717.04 vs. 1,595.5 ¡¾ 703.94, P = 0.001). Patients with post-coronavirus-onset ulcerative colitis had significantly higher Pediatric Ulcerative Colitis Activity Index scores than those with previous outbreaks (48 ¡¾ 17 vs. 36 ¡¾ 15, P = 0.004). In the initial treatment of Crohn¡¯s disease, the use of 5-aminosalicylic acid (5-ASA) and steroids significantly decreased (P = 0.006 and 0.001, respectively), and enteral nutrition and the use of infliximab increased significantly (P = 0.045 and 0.009, respectively). There was a significant increase in azathioprine use during the initial treatment of ulcerative colitis (P = 0.020).
Conclusion: Regardless of the COVID-19 pandemic, the number of patients with PIBD is increasing significantly annually in Korea. The initial management trends for PIBD have also changed. More research is needed to establish appropriate treatment guidelines considering the epidemiological and clinical characteristics of Korean PIBD.
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Inflammatory Bowel Disease, Pediatric, COVID-19, Occurrence, Management
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In Crohn¡¯s disease, patients with post-coronavirus outbreaks had significantly higher fecal calprotectin levels than those with previous onset (1,339.4 ¡¾ 717.04 vs. 1,595.5 ¡¾ 703.94, P = 0.001). Regardless of the COVID-19 pandemic, the number of patients with PIBD is increasing significantly annually in Korea.